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Citalopram (Celexa, Seropram, Cipramil) - Counteractions

Abstract: Cautions when combining citalopram with other drugs.

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Citalopram (Celexa, Seropram, Cipramil) - Counteractions

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Question(s): 
Written by: , lecturer of Psychiatry in the University of Ioannina Medical School, Greece. Eva Gerasi, postgraduate student in the Department of Psychiatry, University Hospital of Ioannina, Greece.
First version: 22 Jul 2008.
Latest revision: 22 Jul 2008.

What other drugs will affect citalopram (Celexa, Seropram, Cipramil)?

Answer:

  • Citalopram should not be taken if the patient has taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. A dangerous drug interaction can occur when citalopram is combined with any of these medications.
  • Before taking citalopram, the patient should tell his/her doctor if he/she is taking any of the following medicines:
    • another antidepressant such as fluoxetine (Prozac), fluvoxamine (Luvox), sertraline (Zoloft), paroxetine (Paxil), trazodone (Desyrel), or nefazodone (Serzone);
    • a tricyclic antidepressant such as amitriptyline (Elavil), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others;
    • a seizure medication including carbamazepine (Tegretol) or felbamate (Felbatol);
    • a stomach medicine such as cimetidine (Tagamet, Tagamet HB), ranitidine (Zantac, Zantac 75), or omeprazole (Prilosec);
    • an antibiotic such as erythromycin (Eryc-Tab, E-Mycin, E.E.S., Erythrocin, P.C.E., others) or clarithromycin (Biaxin);
    • an antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);
    • a migraine medication such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), or zolmitriptan (Zomig);
    • the asthma medication zafirlukast (Accolate); or
    • lithium (Eskalith, Lithobid, Lithonate, Lithotabs).

    They may not be able to take citalopram, or they may require a dosage adjustment or special monitoring during treatment if they are taking any of the medicines listed above.
  • Drugs other than those listed here may also interact with citalopram. Patients should talk to their doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
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