- Presentation of obsessive-compulsive disorder (OCD) or tic/tourette syndrome.
- Early onset (prepubertal, in early childhood)
- Sudden beginning or worsening (exacerbations) of symptoms
- Additional neurological problems (motoric dysfunction) associated with this worsening of OCD symptoms
- Clinical evidence in blood tests (GABHS) associated with severity of symptoms
The proposed poststreptococcal inflammatory explanations provides a unique opportunity for treatment and prevention, including therapies on the immune system such as blood plasma exchange and intravenous immunoglobulin. A placebo-controlled trial revealed that both intravenous immunoglobulin and plasma exchange were effective in reducing the OCD symptoms (40 and 55% reductions, respectively) for a group of severely ill children in the PANDAS subgroup. Further research is required to determine why the treatments are helpful and to ascertain whether or not antibiotic prevention can help prevent this disorder.
The PANDAS symptoms can come and go, get worse during an infection, get better when the infection is cured.